In proton-therapy clinical practice a constant RBE equal to 1.1 is adopted, regardless of the demonstrated RBE variations, which depends on physical and biological parameters. Among other mechanisms, nuclear interactions might influence the proton-RBE due to secondary heavier particles produced by target fragmentation that can significantly contribute to the total dose: an unwanted and undetermined increase of normal tissues complications probability may occur. The FOOT experiment is designed to study these processes. Target (16O,12C) fragmentation induced by 150−250MeV proton beam will be studied via inverse kinematic approach, where 16O and 12C therapeutic beams, with the same kinetic energy per nucleon of the proton, collide on graphite and hydrocarbons target to provide the cross section on Hydrogen (to explore also the projectile fragmentation). The detector design, the performances and expected resolution results obtained form Monte Carlo study, based on the FLUKA code will be presented.

The FOOT FragmentatiOn Of Target Experiment

Biondi Silvia;Franchini Matteo;Garbini Marco;Mengarelli Alberto;Ridolfi Riccardo;Sartorelli Gabriella;Selvi Marco;Villa Mauro;Zoccoli Antonio;
2019

Abstract

In proton-therapy clinical practice a constant RBE equal to 1.1 is adopted, regardless of the demonstrated RBE variations, which depends on physical and biological parameters. Among other mechanisms, nuclear interactions might influence the proton-RBE due to secondary heavier particles produced by target fragmentation that can significantly contribute to the total dose: an unwanted and undetermined increase of normal tissues complications probability may occur. The FOOT experiment is designed to study these processes. Target (16O,12C) fragmentation induced by 150−250MeV proton beam will be studied via inverse kinematic approach, where 16O and 12C therapeutic beams, with the same kinetic energy per nucleon of the proton, collide on graphite and hydrocarbons target to provide the cross section on Hydrogen (to explore also the projectile fragmentation). The detector design, the performances and expected resolution results obtained form Monte Carlo study, based on the FLUKA code will be presented.
2019
CERN Proceedings, Vol 1 (2019): Proceedings of the 15th International Conference on Nuclear Reaction Mechanisms
305
311
Alexandrov Andrey, Alpat Behcet, Ambrosi Giovanni, Argirò Stefano, Battistoni Giuseppe, Bisogni Maria Giuseppina, Belcari Nicola, Biondi Silvia, Bruni Graziano, Camarlinghi Niccolò, Carra Pietro, Cerello Piergiorgio, Ciarrocchi Esther, Clozza Alberto, Colombi Sofia, De Lellis Giovanni, Del Guerra Alberto, De Simoni Micol, Di Crescenzo Antonia, Donetti Marco, Dong Yunsheng, Durante Marco, Embriaco Alessia, Emde Max, Faccini Riccardo, Ferrero Veronica, Ferroni Fernando, Fiandrini Emanuele, Finck Christian, Fiorina Elisa, Fischetti Marta, Francesconi Marco, Franchini Matteo, Galli Luca, Garbini Marco, Gentile Valerio, Giraudo Giuseppe, Hetzel Ronja, Hild Sebastian, Ionica Maria, Kanxheri Keida, Kraan Aafke Christine, Lante Valeria, Lauria Adele, La Tessa Chiara, Lopez Torres Ernesto, Marafini Michela, Mattei Ilaria , Mengarelli Alberto, Mirabelli Riccardo, Montesi Maria Cristina, Morone Maria Cristina, Morrocchi Matteo, Muraro Silvia, Narici Livio, Pastore Alessandra, Pastrone Nadia, Pennazio Francesco, Placidi Pisana, Pullia Marco, Ramello Luciano, Ridolfi Riccardo, Rosso Valeria, Rovituso Marta, Sanelli Claudio, Sarti Alessio, Sartorelli Gabriella, Sato Osamu, Savazzi Simone, Schiavi Angelo, Schuy Christoph, Scifoni Emanuele, Sciubba Adalberto, Selvi Marco, Servoli Leonello, Silvestre Gianluigi, Sitta Mario, Spighi Roberto, Spiriti Eleuterio, Sportelli Giancarlo, Stahl Achim, Tomassini Sandro, Tommasino Francesco, Traini Giacomo, Valeri Tioukov, Valle Serena Marta, Vanstalle Marie, Villa Mauro, Weber Ulrich, Zoccoli Antonio, Patera Vincenzo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/721881
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