The enzyme nicotinamide nucleotide transhydrogenase (NNT) transfers hydride from NADH to NADP+ coupled to H+ translocation across the inner mitochondrial membrane. In a recent study, Kampjut and Sazanov reveal that the bifunctional NNT mechanism rules the NAD(P)+/NAD(P)H interconversion ratio, which in turn regulates antioxidant defense and sirtuin actions.
Nicotinamide Nucleotide Transhydrogenase as a Sensor of Mitochondrial Biology / Nesci S.; Trombetti F.; Pagliarani A.. - In: TRENDS IN CELL BIOLOGY. - ISSN 0962-8924. - STAMPA. - 30:1(2020), pp. 1-3. [10.1016/j.tcb.2019.11.001]
Nicotinamide Nucleotide Transhydrogenase as a Sensor of Mitochondrial Biology
Nesci S.
;Trombetti F.;Pagliarani A.
2020
Abstract
The enzyme nicotinamide nucleotide transhydrogenase (NNT) transfers hydride from NADH to NADP+ coupled to H+ translocation across the inner mitochondrial membrane. In a recent study, Kampjut and Sazanov reveal that the bifunctional NNT mechanism rules the NAD(P)+/NAD(P)H interconversion ratio, which in turn regulates antioxidant defense and sirtuin actions.File in questo prodotto:
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