The aim of the work was to produce inhalable capreomycin powders using a novel spray-drying technology. A 2(3) factorial design was used to individuate the best working conditions. The maximum desirability was identified at the smallest mean volume diameter (d(v)) and span, and the highest yield. Powders were characterized for size, morphology, flowability and aerodynamic properties. Mathematical models showed a good predictivity with biases lower than 20%. The maximum conformity with desirability criteria was obtained spraying a 10 mg/mL bacitracin solution at 111 degrees C with the 4 mm pore size membrane. By processing capreomycin sulfate with the parameters optimized for bacitracin, an inhalable powder was obtained (i.e., yield of 82%, d(v) of 3.83 mu m, and span of 1.04). By further optimization, capreomycin sulfate powder characteristics were improved (i.e., yield, similar to 71%; dv, 3.25 mm; span, 0.95). After formulation with lactose, emitted dose and respirable fraction of 87% and similar to 27% were obtained, respectively. Two capreomycin sulfate powders with suitable properties for inhalation were produced using the nano spray-dryer B-90. (C) 2014 Elsevier B. V. All rights reserved.

Capreomycin inhalable powders prepared with an innovative spray-drying technique

Blasi P.
;
2014

Abstract

The aim of the work was to produce inhalable capreomycin powders using a novel spray-drying technology. A 2(3) factorial design was used to individuate the best working conditions. The maximum desirability was identified at the smallest mean volume diameter (d(v)) and span, and the highest yield. Powders were characterized for size, morphology, flowability and aerodynamic properties. Mathematical models showed a good predictivity with biases lower than 20%. The maximum conformity with desirability criteria was obtained spraying a 10 mg/mL bacitracin solution at 111 degrees C with the 4 mm pore size membrane. By processing capreomycin sulfate with the parameters optimized for bacitracin, an inhalable powder was obtained (i.e., yield of 82%, d(v) of 3.83 mu m, and span of 1.04). By further optimization, capreomycin sulfate powder characteristics were improved (i.e., yield, similar to 71%; dv, 3.25 mm; span, 0.95). After formulation with lactose, emitted dose and respirable fraction of 87% and similar to 27% were obtained, respectively. Two capreomycin sulfate powders with suitable properties for inhalation were produced using the nano spray-dryer B-90. (C) 2014 Elsevier B. V. All rights reserved.
2014
Schoubben A.; Giovagnoli S.; Tiralti M.C.; Blasi P.; Ricci M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/703534
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