The synthesis of 1,3,4-trisubstituted pyrroles via visible-light mediated photoredox catalyzed condensation of arylazides and aldehydes has been reported herein. The methodology avoids the use of stoichiometric oxidants and provides the corresponding N-containing arenes in good yields (up to 78%) and mild conditions. Mechanistic rationale is provided via a dedicated and combined spectroscopic/experimental investigations.

Visible-Light-Driven Synthesis of 1,3,4-Trisubstituted Pyrroles from Aryl Azides

Yang Liu;Adriano Parodi;Simone Battaglioli;Magda Monari;Marco Bandini
2019

Abstract

The synthesis of 1,3,4-trisubstituted pyrroles via visible-light mediated photoredox catalyzed condensation of arylazides and aldehydes has been reported herein. The methodology avoids the use of stoichiometric oxidants and provides the corresponding N-containing arenes in good yields (up to 78%) and mild conditions. Mechanistic rationale is provided via a dedicated and combined spectroscopic/experimental investigations.
ORGANIC LETTERS
Yang Liu, Adriano Parodi, Simone Battaglioli, Magda Monari, Stefano Protti, Marco Bandini
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/703422
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