The synthesis of 1,3,4-trisubstituted pyrroles via visible-light mediated photoredox catalyzed condensation of arylazides and aldehydes has been reported herein. The methodology avoids the use of stoichiometric oxidants and provides the corresponding N-containing arenes in good yields (up to 78%) and mild conditions. Mechanistic rationale is provided via a dedicated and combined spectroscopic/experimental investigations.
Visible-Light-Driven Synthesis of 1,3,4-Trisubstituted Pyrroles from Aryl Azides / Yang Liu, Adriano Parodi, Simone Battaglioli, Magda Monari, Stefano Protti, Marco Bandini. - In: ORGANIC LETTERS. - ISSN 1523-7060. - ELETTRONICO. - 21:19(2019), pp. 7782-7786. [10.1021/acs.orglett.9b02731]
Visible-Light-Driven Synthesis of 1,3,4-Trisubstituted Pyrroles from Aryl Azides
Yang LiuMethodology
;Adriano ParodiMethodology
;Simone BattaglioliMembro del Collaboration Group
;Magda MonariMethodology
;Marco Bandini
Conceptualization
2019
Abstract
The synthesis of 1,3,4-trisubstituted pyrroles via visible-light mediated photoredox catalyzed condensation of arylazides and aldehydes has been reported herein. The methodology avoids the use of stoichiometric oxidants and provides the corresponding N-containing arenes in good yields (up to 78%) and mild conditions. Mechanistic rationale is provided via a dedicated and combined spectroscopic/experimental investigations.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
