The wide use of Fipronil as insecticide, acaricide and product to control other arthropods in pets and households may determine its indoor presence and cause non-food exposure. The presence of total Fipronil (as sum of the parent drug plus its sulfone metabolite) was determined in samples of residential house-dust, in Italy, by LC-MS Orbitrap, with a reporting limit (RL) of 0.01 mg/kg dry weight. A number of 127 out of 164 samples felt above the RL, and total fipronil followed a skewed distribution, with P50, P75, mean, P90, P95 and maximum values falling at 0.05, 0.53, 2.93, 5.83, 18.2 and 74.1 mg/kg dust, respectively. Fipronil has been reported up to 14 mg/kg level in in indoor dust USA in 2009 (N = 24), whereas sparse of data are available in the EU. Within an “One Health” approach, such evidences highlight the need to consider indoor dust as an aggregated source of exposure in toddlers, due to their mouthing and licking behaviour and time spent in close contact with floor. Moreover, results indicate the persistence of veterinary biocide/drug residues in indoor as an emerging issue to be tackled also in term of the induction of drug resistance in target pests.
Occurrence of fipronil in indoor house-dust in Italy
RONCADA P.;ARMORINI S.;
2018
Abstract
The wide use of Fipronil as insecticide, acaricide and product to control other arthropods in pets and households may determine its indoor presence and cause non-food exposure. The presence of total Fipronil (as sum of the parent drug plus its sulfone metabolite) was determined in samples of residential house-dust, in Italy, by LC-MS Orbitrap, with a reporting limit (RL) of 0.01 mg/kg dry weight. A number of 127 out of 164 samples felt above the RL, and total fipronil followed a skewed distribution, with P50, P75, mean, P90, P95 and maximum values falling at 0.05, 0.53, 2.93, 5.83, 18.2 and 74.1 mg/kg dust, respectively. Fipronil has been reported up to 14 mg/kg level in in indoor dust USA in 2009 (N = 24), whereas sparse of data are available in the EU. Within an “One Health” approach, such evidences highlight the need to consider indoor dust as an aggregated source of exposure in toddlers, due to their mouthing and licking behaviour and time spent in close contact with floor. Moreover, results indicate the persistence of veterinary biocide/drug residues in indoor as an emerging issue to be tackled also in term of the induction of drug resistance in target pests.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
