The preparation and characterization of a whole family of hydrated ionic co-crystals formed by both enantiopure l-proline and racemic dl-proline with LiX (X=Cl, Br, I) are reported. The chiral preference of the lithium cation for homochiral coordination, both in the formation of crystalline conglomerates (with Cl and Br) and racemates (with Cl and I), in which molecules of opposite chirality are confined to distinct crystal layers, is discussed. Dehydration processes for all hydrated crystals have also been investigated.
Ionic Co-Crystal Formation as a Path Towards Chiral Resolution in the Solid State / Shemchuk, Oleksii; Tsenkova, Boryana K.; Braga, Dario; Duarte, M. Teresa*; André, Vânia; Grepioni, Fabrizia. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - STAMPA. - 24:48(2018), pp. 12564-12573. [10.1002/chem.201802446]
Ionic Co-Crystal Formation as a Path Towards Chiral Resolution in the Solid State
Shemchuk, Oleksii;Braga, Dario;Grepioni, Fabrizia
2018
Abstract
The preparation and characterization of a whole family of hydrated ionic co-crystals formed by both enantiopure l-proline and racemic dl-proline with LiX (X=Cl, Br, I) are reported. The chiral preference of the lithium cation for homochiral coordination, both in the formation of crystalline conglomerates (with Cl and Br) and racemates (with Cl and I), in which molecules of opposite chirality are confined to distinct crystal layers, is discussed. Dehydration processes for all hydrated crystals have also been investigated.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
