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EnglishThe Fisher esterification reaction has been exploited for linking a peptide (chlorotoxin) onto the surface of nanocellulose using a Brønsted acid ionic liquid both as a solvent and a catalyst. Indeed, cellulose nanocrystals were functionalized with the peptide thanks to a mild, one-step and organic solvent-free reaction. The obtained nanocellulose showed excellent properties in terms of biocompatibility and internalization in the U87MG glioblastoma cell line, thus demonstrating the possible use of this material as a novel drug delivery carrier.
| Titolo: | One-step esterification of nanocellulose in Brønsted acid Ionic Liquid for delivery to Glioblastoma Cancer cells |
| Autore/i: | CELLANTE, LINA; Costa, Roberta; Monaco, Ilaria; CENACCHI, GIOVANNA; Locatelli, Erica |
| Autore/i Unibo: | |
| Anno: | 2018 |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1039/C7NJ04633B |
| Abstract: | The Fisher esterification reaction has been exploited for linking a peptide (chlorotoxin) onto the surface of nanocellulose using a Brønsted acid ionic liquid both as a solvent and a catalyst. Indeed, cellulose nanocrystals were functionalized with the peptide thanks to a mild, one-step and organic solvent-free reaction. The obtained nanocellulose showed excellent properties in terms of biocompatibility and internalization in the U87MG glioblastoma cell line, thus demonstrating the possible use of this material as a novel drug delivery carrier. |
| Data stato definitivo: | 2019-01-25T15:44:19Z |
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