The Fisher esterification reaction has been exploited for linking a peptide (chlorotoxin) onto the surface of nanocellulose using a Brønsted acid ionic liquid both as a solvent and a catalyst. Indeed, cellulose nanocrystals were functionalized with the peptide thanks to a mild, one-step and organic solvent-free reaction. The obtained nanocellulose showed excellent properties in terms of biocompatibility and internalization in the U87MG glioblastoma cell line, thus demonstrating the possible use of this material as a novel drug delivery carrier.
One-step esterification of nanocellulose in Brønsted acid Ionic Liquid for delivery to Glioblastoma Cancer cells / Cellante, Lina; Costa, Roberta; Monaco, Ilaria; CENACCHI, GIOVANNA; Locatelli, Erica. - In: NEW JOURNAL OF CHEMISTRY. - ISSN 1144-0546. - ELETTRONICO. - 42:(2018), pp. 5237-5242. [10.1039/C7NJ04633B]
One-step esterification of nanocellulose in Brønsted acid Ionic Liquid for delivery to Glioblastoma Cancer cells
CELLANTE, LINA;Costa, Roberta;Monaco, Ilaria;CENACCHI, GIOVANNA;Locatelli, Erica
2018
Abstract
The Fisher esterification reaction has been exploited for linking a peptide (chlorotoxin) onto the surface of nanocellulose using a Brønsted acid ionic liquid both as a solvent and a catalyst. Indeed, cellulose nanocrystals were functionalized with the peptide thanks to a mild, one-step and organic solvent-free reaction. The obtained nanocellulose showed excellent properties in terms of biocompatibility and internalization in the U87MG glioblastoma cell line, thus demonstrating the possible use of this material as a novel drug delivery carrier.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
