A new protocol for the enantioselective direct alpha-heteroarylation of aldehydes with isoquinoline N-oxides, via chiral enamine catalysis, has been successfully developed. High enantiomeric excesses and moderate to good yields were achieved for a variety of alpha-heteroarylated aldehydes.
An organocatalytic enantioselective direct alpha-heteroarylation of aldehydes with isoquinoline N-oxides / Bertuzzi, Giulio; Pecorari, Daniel; Bernardi, Luca; Fochi, Mariafrancesca. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - STAMPA. - 54:32(2018), pp. 3977-3980. [10.1039/c8cc01735b]
An organocatalytic enantioselective direct alpha-heteroarylation of aldehydes with isoquinoline N-oxides
Bertuzzi, Giulio;PECORARI, DANIEL;Bernardi, Luca
;Fochi, Mariafrancesca
2018
Abstract
A new protocol for the enantioselective direct alpha-heteroarylation of aldehydes with isoquinoline N-oxides, via chiral enamine catalysis, has been successfully developed. High enantiomeric excesses and moderate to good yields were achieved for a variety of alpha-heteroarylated aldehydes.File in questo prodotto:
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