Phosphorescent iridium-containing nanomicelles: synthesis, characterization and preliminary applications in nanomedical imaging

Monaco, I.; Maturi, M.; Matteucci, E.; Locatelli, E.; Baschieri, A.; Zani, P.; Armanetti, P.; Menichetti, L.; Sambri, L.; Comes Franchini, M.

doi:10.1039/C8RA05368E

Diagnostic nanomedicine constantly needs for development of novel contrast agents with intrinsic imaging capability. Phosphorescent Ir(III)-complexes represent good candidates when delivered through polymeric nanoparticles. In this work, we propose a biocompatible nanoparticle made from an intrisically phosphorescent copolymer, synthesized directly with the imaging tag present onto its backbone. Polymeric nanoparticles can be obtained with the exact amount of phosphorescent moiety needed to maximize the output signal. Complete characterization and ex-vivo studies confirmed that this nanosystem is suitable as future diagnostic tool.

Titolo:	Phosphorescent iridium-containing nanomicelles: synthesis, characterization and preliminary applications in nanomedical imaging
Autore/i:	Monaco, I.; Maturi, M.; Matteucci, E.; Locatelli, E.; Baschieri, A.; Zani, P.; Armanetti, P.; Menichetti, L.; Sambri, L.; Comes Franchini, M.
Autore/i Unibo:	MONACO, ILARIA MATURI, MIRKO MATTEUCCI, ELIA LOCATELLI, ERICA BASCHIERI, ANDREA ZANI, PAOLO Armanetti, P. Menichetti, L. SAMBRI, LETIZIA COMES FRANCHINI, MAURO mostra contributor esterni nascondi contributor esterni
Anno:	2018
Rivista:	RSC ADVANCES
Digital Object Identifier (DOI):	http://dx.doi.org/10.1039/C8RA05368E
Abstract:	Diagnostic nanomedicine constantly needs for development of novel contrast agents with intrinsic imaging capability. Phosphorescent Ir(III)-complexes represent good candidates when delivered through polymeric nanoparticles. In this work, we propose a biocompatible nanoparticle made from an intrisically phosphorescent copolymer, synthesized directly with the imaging tag present onto its backbone. Polymeric nanoparticles can be obtained with the exact amount of phosphorescent moiety needed to maximize the output signal. Complete characterization and ex-vivo studies confirmed that this nanosystem is suitable as future diagnostic tool.
Data stato definitivo:	2019-01-09T11:16:15Z
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