Despite the recent progress that has been made in the understanding and treatment of acute lymphoblastic leukemia (ALL), the outcome is still dismal in adult ALL cases. Several studies in solid tumors identified high expression of WEE1 kinase as a poor prognostic factor and reported its role as a cancer-conserving oncogene that protects cancer cells from DNA damage. Therefore, the targeted inhibition of WEE1 kinase has emerged as a rational strategy to sensitize cancer cells to antineoplastic compounds, which we evaluate in this study.
Targeting WEE1 to enhance conventional therapies for acute lymphoblastic leukemia
Ghelli Luserna Di Rorà, Andrea;Imbrogno, Enrica;Ferrari, Anna;Robustelli, Valentina;Righi, Simona;Sabattini, Elena;Testoni, Nicoletta;Baldazzi, Carmen;Papayannidis, Cristina;Abbenante, Maria Chiara;Marconi, Giovanni;Paolini, Stefania;Parisi, Sarah;Sartor, Chiara;Fontana, Maria Chiara;Iacobucci, Ilaria;Cavo, Michele;Martinelli, Giovanni
2018
Abstract
Despite the recent progress that has been made in the understanding and treatment of acute lymphoblastic leukemia (ALL), the outcome is still dismal in adult ALL cases. Several studies in solid tumors identified high expression of WEE1 kinase as a poor prognostic factor and reported its role as a cancer-conserving oncogene that protects cancer cells from DNA damage. Therefore, the targeted inhibition of WEE1 kinase has emerged as a rational strategy to sensitize cancer cells to antineoplastic compounds, which we evaluate in this study.File in questo prodotto:
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