Defining the severity of ARDS using PaO2/FIO2 , 150 as a surrogate for life-threatening edema is a promising approach. However, ARDS is a heterogeneous syndrome, and identifying a treatment-responsive hyperinflammatory subtype across the PaO2/FIO2 severity spectrum suggests the fundamental limitations of using physiological or anatomic variables alone to understand and treat the underlying mechanisms that lead to ARDS, let alone to stratify risk. We suspect that both approaches will be complementary and will require prospective evaluation for their predictive enrichment potential
Assessing risk and treatment responsiveness in ARDS: Beyond Physiology / Sorbo, Lorenzo Del; Nava, Stefano; Rubenfeld, Gordon; Thompson, Taylor; Marco Ranieri, V.. - In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. - ISSN 1073-449X. - STAMPA. - 197:12(2018), pp. 1516-1518. [10.1164/rccm.201802-0273ED]
Assessing risk and treatment responsiveness in ARDS: Beyond Physiology
Nava, Stefano;Marco Ranieri, V.
2018
Abstract
Defining the severity of ARDS using PaO2/FIO2 , 150 as a surrogate for life-threatening edema is a promising approach. However, ARDS is a heterogeneous syndrome, and identifying a treatment-responsive hyperinflammatory subtype across the PaO2/FIO2 severity spectrum suggests the fundamental limitations of using physiological or anatomic variables alone to understand and treat the underlying mechanisms that lead to ARDS, let alone to stratify risk. We suspect that both approaches will be complementary and will require prospective evaluation for their predictive enrichment potentialI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
