While values of arterial pressure during sleep are predictive of cardiovascular risk, the autonomic mechanisms underlying the cardiovascular effects of sleep remain poorly understood. Here, we assess the autonomic mechanisms of the cardiovascular effects of sleep in C57Bl/6J mice, taking advantage of a novel technique for continuous intraperitoneal infusion of autonomic blockers. Our results indicate that non-REM sleep decreases arterial pressure by decreasing sympathetic vasoconstriction, decreases heart rate by balancing parasympathetic activation and sympathetic withdrawal, and increases cardiac baroreflex sensitivity mainly by increasing fluctuations in parasympathetic activity. Our results also indicate that REM sleep increases arterial pressure by increasing sympathetic activity to the heart and blood vessels, and increases heart rate, at least in part, by increasing cardiac sympathetic activity. These results provide a framework for generating and testing hypotheses on cardiovascular derangements during sleep in mouse models and human patients.

Modulation of sympathetic vasoconstriction is critical for the effects of sleep on arterial pressure in mice / Lo Martire, Viviana; Silvani, Alessandro; Alvente, Sara; Bastianini, Stefano; Berteotti, Chiara; Valli, Alice; Zoccoli, Giovanna. - In: THE JOURNAL OF PHYSIOLOGY. - ISSN 0022-3751. - STAMPA. - 596:4(2018), pp. 591-608. [10.1113/JP275353]

Modulation of sympathetic vasoconstriction is critical for the effects of sleep on arterial pressure in mice

Lo Martire, Viviana;Silvani, Alessandro;Alvente, Sara;Bastianini, Stefano;Berteotti, Chiara;Valli, Alice;Zoccoli, Giovanna
2018

Abstract

While values of arterial pressure during sleep are predictive of cardiovascular risk, the autonomic mechanisms underlying the cardiovascular effects of sleep remain poorly understood. Here, we assess the autonomic mechanisms of the cardiovascular effects of sleep in C57Bl/6J mice, taking advantage of a novel technique for continuous intraperitoneal infusion of autonomic blockers. Our results indicate that non-REM sleep decreases arterial pressure by decreasing sympathetic vasoconstriction, decreases heart rate by balancing parasympathetic activation and sympathetic withdrawal, and increases cardiac baroreflex sensitivity mainly by increasing fluctuations in parasympathetic activity. Our results also indicate that REM sleep increases arterial pressure by increasing sympathetic activity to the heart and blood vessels, and increases heart rate, at least in part, by increasing cardiac sympathetic activity. These results provide a framework for generating and testing hypotheses on cardiovascular derangements during sleep in mouse models and human patients.
2018
Modulation of sympathetic vasoconstriction is critical for the effects of sleep on arterial pressure in mice / Lo Martire, Viviana; Silvani, Alessandro; Alvente, Sara; Bastianini, Stefano; Berteotti, Chiara; Valli, Alice; Zoccoli, Giovanna. - In: THE JOURNAL OF PHYSIOLOGY. - ISSN 0022-3751. - STAMPA. - 596:4(2018), pp. 591-608. [10.1113/JP275353]
Lo Martire, Viviana; Silvani, Alessandro; Alvente, Sara; Bastianini, Stefano; Berteotti, Chiara; Valli, Alice; Zoccoli, Giovanna
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/627999
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