This study aims to refine the designation for single hepatocellular carcinoma (HCC) >5 cm by comparing the postresection prognosis of these patients with those who have a single-tumor â¤5 cm and those with stage B. Patients with a single-tumor were classified into subgroups based on diameter. Of the 1132 patients analyzed, 426 had a single-tumor >2 and â¤5 cm; 229, a single-tumor >5 and â¤8 cm; 52, a single-tumor >8 and < 10 cm; 150, a single-tumor â¥10 cm; and 275, stage B. Hospital mortality and complications increased with tumor size among the single-tumor subgroups and median survival decreased with increasing of tumor size. Overall survival (OS) among patients with a single-tumor >5 cm was significantly lower than among patients with a single-tumor >2 and â¤5 cm (P ⤠.001), but significantly higher than among patients with clearly stage B (P ⤠.001). Patients with a single-tumor >5 and â¤8 cm showed lower OS than patients with a single-tumor >2 and â¤5 cm (P < .001). Patients with a single-tumor >8 and <10 cm or a single-tumor â¥10 cm showed lower OS than patients with a single-tumor >5 and â¤8 cm (P = .033 and.006), and similar OS to patients with stage B (P = .323). Patients with a single-tumor >5 and â¤8 cm may be assigned to a new stage between early and intermediate. Patients with a single-tumor >8 cm may be assigned to intermediate stage.
Optimizing stage of single large hepatocellular carcinoma
Cucchetti, Alessandro;
2017
Abstract
This study aims to refine the designation for single hepatocellular carcinoma (HCC) >5 cm by comparing the postresection prognosis of these patients with those who have a single-tumor â¤5 cm and those with stage B. Patients with a single-tumor were classified into subgroups based on diameter. Of the 1132 patients analyzed, 426 had a single-tumor >2 and â¤5 cm; 229, a single-tumor >5 and â¤8 cm; 52, a single-tumor >8 and < 10 cm; 150, a single-tumor â¥10 cm; and 275, stage B. Hospital mortality and complications increased with tumor size among the single-tumor subgroups and median survival decreased with increasing of tumor size. Overall survival (OS) among patients with a single-tumor >5 cm was significantly lower than among patients with a single-tumor >2 and â¤5 cm (P ⤠.001), but significantly higher than among patients with clearly stage B (P ⤠.001). Patients with a single-tumor >5 and â¤8 cm showed lower OS than patients with a single-tumor >2 and â¤5 cm (P < .001). Patients with a single-tumor >8 and <10 cm or a single-tumor â¥10 cm showed lower OS than patients with a single-tumor >5 and â¤8 cm (P = .033 and.006), and similar OS to patients with stage B (P = .323). Patients with a single-tumor >5 and â¤8 cm may be assigned to a new stage between early and intermediate. Patients with a single-tumor >8 cm may be assigned to intermediate stage.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.