The late sodium current inhibitor ranolazine reverses the main electrophysiological and mechanical abnormalities of human hypertrophic cardiomyopathy (HCM) cardiomyocytes in vitro, suggesting potential clinical benefit. We aimed to assess the effect of ranolazine on functional capacity, symptomatic status, diastolic function, and arrhythmias in HCM.

Efficacy of Ranolazine in Patients With Symptomatic Hypertrophic Cardiomyopathy: The RESTYLE-HCM Randomized, Double-Blind, Placebo-Controlled Study / Olivotto, Iacopo; Camici, Paolo G; Merlini, Piera Angelica; Rapezzi, Claudio; Patten, Monica; Climent, Vicent; Sinagra, Gianfranco; Tomberli, Benedetta; Marin, Francisco; Ehlermann, Philipp; Maier, Lars S; Fornaro, Alessandra; Jacobshagen, Claudius; Ganau, Antonello; Moretti, Luciano; Hernandez Madrid, Antonio; Coppini, Raffaele; Reggiardo, Giorgio; Poggesi, Corrado; Fattirolli, Francesco; Belardinelli, Luiz; Gensini, Gianfranco; Mugelli, Alessandro. - In: CIRCULATION. HEART FAILURE. - ISSN 1941-3289. - STAMPA. - 11:1(2018), pp. e004124.1-e004124.10. [10.1161/CIRCHEARTFAILURE.117.004124]

Efficacy of Ranolazine in Patients With Symptomatic Hypertrophic Cardiomyopathy: The RESTYLE-HCM Randomized, Double-Blind, Placebo-Controlled Study

Rapezzi, Claudio;
2018

Abstract

The late sodium current inhibitor ranolazine reverses the main electrophysiological and mechanical abnormalities of human hypertrophic cardiomyopathy (HCM) cardiomyocytes in vitro, suggesting potential clinical benefit. We aimed to assess the effect of ranolazine on functional capacity, symptomatic status, diastolic function, and arrhythmias in HCM.
2018
Efficacy of Ranolazine in Patients With Symptomatic Hypertrophic Cardiomyopathy: The RESTYLE-HCM Randomized, Double-Blind, Placebo-Controlled Study / Olivotto, Iacopo; Camici, Paolo G; Merlini, Piera Angelica; Rapezzi, Claudio; Patten, Monica; Climent, Vicent; Sinagra, Gianfranco; Tomberli, Benedetta; Marin, Francisco; Ehlermann, Philipp; Maier, Lars S; Fornaro, Alessandra; Jacobshagen, Claudius; Ganau, Antonello; Moretti, Luciano; Hernandez Madrid, Antonio; Coppini, Raffaele; Reggiardo, Giorgio; Poggesi, Corrado; Fattirolli, Francesco; Belardinelli, Luiz; Gensini, Gianfranco; Mugelli, Alessandro. - In: CIRCULATION. HEART FAILURE. - ISSN 1941-3289. - STAMPA. - 11:1(2018), pp. e004124.1-e004124.10. [10.1161/CIRCHEARTFAILURE.117.004124]
Olivotto, Iacopo; Camici, Paolo G; Merlini, Piera Angelica; Rapezzi, Claudio; Patten, Monica; Climent, Vicent; Sinagra, Gianfranco; Tomberli, Benedetta; Marin, Francisco; Ehlermann, Philipp; Maier, Lars S; Fornaro, Alessandra; Jacobshagen, Claudius; Ganau, Antonello; Moretti, Luciano; Hernandez Madrid, Antonio; Coppini, Raffaele; Reggiardo, Giorgio; Poggesi, Corrado; Fattirolli, Francesco; Belardinelli, Luiz; Gensini, Gianfranco; Mugelli, Alessandro
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/618885
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