Psoriasis is a multi-systemic chronic inflammatory disease that affects about 1.5-3% of the general population, of which almost 20% suffer from a moderate-severe form. Those patients can be treated with a systemic agent, and, in case of scarce response or contraindications, they may require a biologic therapy, such as tumor necrosis factor or interleukin-12/23 inhibitors. When also those agents fail, clinicians face a true therapeutic challenge. We report a case series of multi-failure 16 patients, successfully treated with secukinumab, a fully human monoclonal antibody that selectively neutralizes interleukin-17A, recently approved for the treatment of plaque psoriasis, psoriatic arthritis and ankylosing spondylitis.

Secukinumab in multi-failure psoriatic patients: the last hope?

Magnano, M;Loi, C;Patrizi, A;Sgubbi, P;Balestri, R;Rech, G;TASIN, LUCA;OFFIDANI, ANNA MARIA;Bardazzi, F.
2018

Abstract

Psoriasis is a multi-systemic chronic inflammatory disease that affects about 1.5-3% of the general population, of which almost 20% suffer from a moderate-severe form. Those patients can be treated with a systemic agent, and, in case of scarce response or contraindications, they may require a biologic therapy, such as tumor necrosis factor or interleukin-12/23 inhibitors. When also those agents fail, clinicians face a true therapeutic challenge. We report a case series of multi-failure 16 patients, successfully treated with secukinumab, a fully human monoclonal antibody that selectively neutralizes interleukin-17A, recently approved for the treatment of plaque psoriasis, psoriatic arthritis and ankylosing spondylitis.
2018
Magnano, M; Loi, C; Patrizi, A; Sgubbi, P; Balestri, R; Rech, G; Tasin, L; Girardelli, C. R; Conti, A; Odorici, G; Campanati, A; Offidani, A. M; Bardazzi, F.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/617859
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