C60@lysozyme showed significant visible light-induced singlet oxygen generation in water, indicating the potential of this hybrid as an agent for photodynamic therapy. The reactive oxygen species (ROS) concentration generated by C60@lysozyme during irradiation depends on the light source, the irradiation time and the concentration of the hybrid. C60@lysozyme significantly reduced the HeLa cell viability in response to visible light irradiation. The generation of H2O2, due to the photoactivity of C60@lysozyme, causes cell death via easy permeation of hydrogen peroxide through the cell membrane and activation of endogenous ROS production.
C60@lysozyme: A new photosensitizing agent for photodynamic therapy / Soldã , A.; Cantelli, A.; Di Giosia, M.; Montalti, M.; Zerbetto, F.; Rapino, S.; Calvaresi, M.. - In: JOURNAL OF MATERIALS CHEMISTRY. B. - ISSN 2050-7518. - ELETTRONICO. - 5:32(2017), pp. 6608-6615. [10.1039/c7tb00800g]
C60@lysozyme: A new photosensitizing agent for photodynamic therapy
Cantelli, A.;Di Giosia, M.;Montalti, M.;Zerbetto, F.;Rapino, S.;Calvaresi, M.
2017
Abstract
C60@lysozyme showed significant visible light-induced singlet oxygen generation in water, indicating the potential of this hybrid as an agent for photodynamic therapy. The reactive oxygen species (ROS) concentration generated by C60@lysozyme during irradiation depends on the light source, the irradiation time and the concentration of the hybrid. C60@lysozyme significantly reduced the HeLa cell viability in response to visible light irradiation. The generation of H2O2, due to the photoactivity of C60@lysozyme, causes cell death via easy permeation of hydrogen peroxide through the cell membrane and activation of endogenous ROS production.File | Dimensione | Formato | |
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