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Bruton tyrosine kinase is a clinically validated target in mantle cell lymphoma. Acalabrutinib (ACP-196) is a highly selective, potent Bruton tyrosine kinase inhibitor developed to minimise off-target activity.

Acalabrutinib in relapsed or refractory mantle cell lymphoma (ACE-LY-004): a single-arm, multicentre, phase 2 trial / Wang, Michael; Rule, Simon; Zinzani, Pier Luigi; Goy, Andre; Casasnovas, Olivier; Smith, Stephen D; Damaj, Gandhi; Doorduijn, Jeanette; Lamy, Thierry; Morschhauser, Franck; Panizo, Carlos; Shah, Bijal; Davies, Andrew; Eek, Richard; Dupuis, Jehan; Jacobsen, Eric; Kater, Arnon P; Le Gouill, Steven; Oberic, Lucie; Robak, Taduesz; Covey, Todd; Dua, Richa; Hamdy, Ahmed; Huang, Xin; Izumi, Raquel; Patel, Priti; Rothbaum, Wayne; Slatter, J. Greg; Jurczak, Wojciech. - In: THE LANCET. - ISSN 0099-5355. - ELETTRONICO. - 391:10121(2018), pp. 659-667. [10.1016/S0140-6736(17)33108-2]

Acalabrutinib in relapsed or refractory mantle cell lymphoma (ACE-LY-004): a single-arm, multicentre, phase 2 trial

Zinzani, Pier Luigi;
2018

Abstract

Bruton tyrosine kinase is a clinically validated target in mantle cell lymphoma. Acalabrutinib (ACP-196) is a highly selective, potent Bruton tyrosine kinase inhibitor developed to minimise off-target activity.
2018
THE LANCET
Acalabrutinib in relapsed or refractory mantle cell lymphoma (ACE-LY-004): a single-arm, multicentre, phase 2 trial / Wang, Michael; Rule, Simon; Zinzani, Pier Luigi; Goy, Andre; Casasnovas, Olivier; Smith, Stephen D; Damaj, Gandhi; Doorduijn, Jeanette; Lamy, Thierry; Morschhauser, Franck; Panizo, Carlos; Shah, Bijal; Davies, Andrew; Eek, Richard; Dupuis, Jehan; Jacobsen, Eric; Kater, Arnon P; Le Gouill, Steven; Oberic, Lucie; Robak, Taduesz; Covey, Todd; Dua, Richa; Hamdy, Ahmed; Huang, Xin; Izumi, Raquel; Patel, Priti; Rothbaum, Wayne; Slatter, J. Greg; Jurczak, Wojciech. - In: THE LANCET. - ISSN 0099-5355. - ELETTRONICO. - 391:10121(2018), pp. 659-667. [10.1016/S0140-6736(17)33108-2]
Wang, Michael; Rule, Simon; Zinzani, Pier Luigi; Goy, Andre; Casasnovas, Olivier; Smith, Stephen D; Damaj, Gandhi; Doorduijn, Jeanette; Lamy, Thierry; Morschhauser, Franck; Panizo, Carlos; Shah, Bijal; Davies, Andrew; Eek, Richard; Dupuis, Jehan; Jacobsen, Eric; Kater, Arnon P; Le Gouill, Steven; Oberic, Lucie; Robak, Taduesz; Covey, Todd; Dua, Richa; Hamdy, Ahmed; Huang, Xin; Izumi, Raquel; Patel, Priti; Rothbaum, Wayne; Slatter, J. Greg; Jurczak, Wojciech
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/615095
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