Peripapillar and nerve head vessel density (VD) was measured in 10 patients affected by Dominant optic atrophy (DOA) using optical coherence tomography angiography (OCT-A) and compared to the measurements of 15 age- and gender-matched controls.DOA patients showed VD reduction, mostly in the temporal and inferotemporal peripapillary sectors, according to the preferential involvement of the papillomacular bundle. Despite poor best-corrected visual acuity (BCVA), OCT-A revealed good repeatability. VD correlated with functional (mean deviation of visual field and BCVA) and structural (retinal nerve fiber layer thickness) parameters and could be a non-invasive, quantitative tool for the monitoring of the disease and of the therapeutic approaches.
Optical coherence tomography angiography of the peripapillary retina and optic nerve head in dominant optic atrophy / Balducci, Nicole; Ciardella, Antonio; Gattegna, Roberto; Zhou, Qienyuan; Cascavilla, Maria Lucia; LA MORGIA, Chiara; Savini, Giacomo; Parisi, Vincenzo; Bandello, Francesco; Carelli, Valerio; Barboni, Piero. - In: MITOCHONDRION. - ISSN 1567-7249. - STAMPA. - 36:(2017), pp. 60-65. [10.1016/j.mito.2017.03.002]
Optical coherence tomography angiography of the peripapillary retina and optic nerve head in dominant optic atrophy
LA MORGIA, CHIARA;CARELLI, VALERIO;
2017
Abstract
Peripapillar and nerve head vessel density (VD) was measured in 10 patients affected by Dominant optic atrophy (DOA) using optical coherence tomography angiography (OCT-A) and compared to the measurements of 15 age- and gender-matched controls.DOA patients showed VD reduction, mostly in the temporal and inferotemporal peripapillary sectors, according to the preferential involvement of the papillomacular bundle. Despite poor best-corrected visual acuity (BCVA), OCT-A revealed good repeatability. VD correlated with functional (mean deviation of visual field and BCVA) and structural (retinal nerve fiber layer thickness) parameters and could be a non-invasive, quantitative tool for the monitoring of the disease and of the therapeutic approaches.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.