Much of our understanding of the biology of MYCN amplification in neuroblastoma is based on the exploration of transcriptional activity of MYCN. Powers and colleagues, in a paper in Nature, now show that MYCN RNA also has an important role in neuroblastoma in addition to MYCN protein production. Their findings place the Let-7 microRNA family front and centre in neuroblastoma biology.
Letting the breaks off MYCN
PERINI, GIOVANNI;MILAZZO, GIORGIO;
2016
Abstract
Much of our understanding of the biology of MYCN amplification in neuroblastoma is based on the exploration of transcriptional activity of MYCN. Powers and colleagues, in a paper in Nature, now show that MYCN RNA also has an important role in neuroblastoma in addition to MYCN protein production. Their findings place the Let-7 microRNA family front and centre in neuroblastoma biology.File in questo prodotto:
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