the presence and inducibility of CYP enzymes belonging to the family 1 (CYP 1A1, 1A2 and 1B!) and AhR have been studied in liver, lung, kidney and heart of control and beta-naphtoflavone (betaNF)-treated pigs. Segments of so far undescribed genes for porcine CYP 1A1, 1A2, 1B1 and Ahr were identified by RT_PCR and their sequences found to be higly homologous to those of the corresponding human genes. Our results demonstrated a differential expression and regulation of the AhR-mediated CYP genes in liver, lung, kidney and heart of the pig-naphtoflavone.

Inducibility of AhR-regulated CYP genes by beta-naphtoflavone in the liver, lung, kidney and heart of the pig

MARVASI, LUIGI;ZAGHINI, ANNA;
2007

Abstract

the presence and inducibility of CYP enzymes belonging to the family 1 (CYP 1A1, 1A2 and 1B!) and AhR have been studied in liver, lung, kidney and heart of control and beta-naphtoflavone (betaNF)-treated pigs. Segments of so far undescribed genes for porcine CYP 1A1, 1A2, 1B1 and Ahr were identified by RT_PCR and their sequences found to be higly homologous to those of the corresponding human genes. Our results demonstrated a differential expression and regulation of the AhR-mediated CYP genes in liver, lung, kidney and heart of the pig-naphtoflavone.
2007
Chirulli V.; Marvasi L.; Zaghini A.; Fiorio R.; Longo V.; Grvasi P.G.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/59548
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