Primary mediastinal B-cell lymphoma is characterized by a high chance of cure, and cured patients have a long disease-free life-expectancy; however, prognosis is severe in the case of relapsed or refractory disease. The initial use of the most effective chemoimmunotherapy regimen is therefore crucial. Understanding who will benefit from postinduction radiotherapy is also of paramount importance; positron emission tomography may be a reliable guide for physicians in determining which patients will require consolidation. New drugs with mechanisms of action including the most relevant biologic features of the tumor may allow better disease control.
Optimizing Outcomes in Primary Mediastinal B-cell Lymphoma / Zinzani, PIER LUIGI; Broccoli, Alessandro. - In: HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA. - ISSN 0889-8588. - STAMPA. - 30:6(2016), pp. 1261-1275. [10.1016/j.hoc.2016.07.011]
Optimizing Outcomes in Primary Mediastinal B-cell Lymphoma
ZINZANI, PIER LUIGI;BROCCOLI, ALESSANDRO
2016
Abstract
Primary mediastinal B-cell lymphoma is characterized by a high chance of cure, and cured patients have a long disease-free life-expectancy; however, prognosis is severe in the case of relapsed or refractory disease. The initial use of the most effective chemoimmunotherapy regimen is therefore crucial. Understanding who will benefit from postinduction radiotherapy is also of paramount importance; positron emission tomography may be a reliable guide for physicians in determining which patients will require consolidation. New drugs with mechanisms of action including the most relevant biologic features of the tumor may allow better disease control.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.