Neuroactive steroids may play a role in the pathophysiology of psychotic disorders, but few studies examined this issue. We compared serum levels of cortisol, testosterone, dehydroepiandrosterone, and progesterone between a representative sample of first-episode psychosis (FEP) patients and age- and gender-matched healthy subjects. Furthermore, we analyzed the associations between neuroactive steroids levels and the severity of psychotic symptom dimensions. Male patients had lower levels of progesterone than controls (p = 0.03). Progesterone levels were inversely associated with the severity of positive symptoms (p = 0.007). Consistent with preclinical findings, results suggest that progesterone might have a role in the pathophysiology of psychotic disorders.
Neuroactive Steroids in First-Episode Psychosis: A Role for Progesterone? / Belvederi Murri, Martino; Fanelli, Flaminia; Pagotto, Uberto; Bonora, Elena; Triolo, Federico; Chiri, Luigi; Allegri, Fabio; Mezzullo, Marco; Menchetti, Marco; Mondelli, Valeria; Pariante, Carmine; Berardi, Domenico; Tarricone, Ilaria. - In: SCHIZOPHRENIA RESEARCH AND TREATMENT. - ISSN 2090-2085. - ELETTRONICO. - 2016:(2016), pp. 1942828.1-1942828.6. [10.1155/2016/1942828]
Neuroactive Steroids in First-Episode Psychosis: A Role for Progesterone?
FANELLI, FLAMINIA;PAGOTTO, UBERTO;BONORA, ELENA;TRIOLO, FEDERICO;CHIRI, LUIGI ROCCO;MEZZULLO, MARCO;MENCHETTI, MARCO;BERARDI, DOMENICO;TARRICONE, ILARIA
2016
Abstract
Neuroactive steroids may play a role in the pathophysiology of psychotic disorders, but few studies examined this issue. We compared serum levels of cortisol, testosterone, dehydroepiandrosterone, and progesterone between a representative sample of first-episode psychosis (FEP) patients and age- and gender-matched healthy subjects. Furthermore, we analyzed the associations between neuroactive steroids levels and the severity of psychotic symptom dimensions. Male patients had lower levels of progesterone than controls (p = 0.03). Progesterone levels were inversely associated with the severity of positive symptoms (p = 0.007). Consistent with preclinical findings, results suggest that progesterone might have a role in the pathophysiology of psychotic disorders.File | Dimensione | Formato | |
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