Pre-ribosomal complex RPL5/RPL11/5S rRNA (5S RNP) is considered the central MDM2 inhibitory complex that control p53 stabilization during ribosome biogenesis inhibition. Despite its role is well defined, the dynamic of 5S RNP assembly still requires further characterization. In the present work, we report that MDM2 inhibition is dependent by a pre-existing population of 5S rRNA.
The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition / Onofrillo, Carmine; Galbiati, Alice; Montanaro, Lorenzo; Derenzini, Massimo. - In: ONCOTARGET. - ISSN 1949-2553. - ELETTRONICO. - 8:3(2017), pp. 4257-4267. [10.18632/oncotarget.13833]
The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition
ONOFRILLO, CARMINE;GALBIATI, ALICE;MONTANARO, LORENZO;DERENZINI, MASSIMO
2017
Abstract
Pre-ribosomal complex RPL5/RPL11/5S rRNA (5S RNP) is considered the central MDM2 inhibitory complex that control p53 stabilization during ribosome biogenesis inhibition. Despite its role is well defined, the dynamic of 5S RNP assembly still requires further characterization. In the present work, we report that MDM2 inhibition is dependent by a pre-existing population of 5S rRNA.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
