The lack of early diagnosis, progression markers and effective pharmacological treatment has dramatic unfavourable effects on clinical outcomes in patients with peripheral artery disease (PAD). Addressing these issues will require dissecting the molecular mechanisms underlying this disease. We sought to characterize the Notch signaling and atherosclerosis relevant markers in lesions from femoral arteries of symptomatic PAD patients.
Distinct gene expression profiles associated with Notch ligands Delta-like 4 and Jagged1 in plaque material from peripheral artery disease patients: a pilot study / Aquila, Giorgio; Fortini, Cinzia; Pannuti, Antonio; Delbue, Serena; Pannella, Micaela; Morelli, Marco Bruno; Caliceti, Cristiana; Castriota, Fausto; de Mattei, Monica; Ongaro, Alessia; Pellati, Agnese; Ferrante, Pasquale; Miele, Lucio; Tavazzi, Luigi; Ferrari, Roberto; Rizzo, Paola; Cremonesi, Alberto. - In: JOURNAL OF TRANSLATIONAL MEDICINE. - ISSN 1479-5876. - ELETTRONICO. - 98:15(2017), pp. 1-14. [10.1186/s12967-017-1199-3]
Distinct gene expression profiles associated with Notch ligands Delta-like 4 and Jagged1 in plaque material from peripheral artery disease patients: a pilot study
FORTINI, CINZIA;PANNELLA, MICAELA;CALICETI, CRISTIANA;CASTRIOTA, FAUSTO;FERRARI, ROBERTO;CREMONESI, ALBERTO
2017
Abstract
The lack of early diagnosis, progression markers and effective pharmacological treatment has dramatic unfavourable effects on clinical outcomes in patients with peripheral artery disease (PAD). Addressing these issues will require dissecting the molecular mechanisms underlying this disease. We sought to characterize the Notch signaling and atherosclerosis relevant markers in lesions from femoral arteries of symptomatic PAD patients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
