In this work we report the stimulation of astrocytic calcium signalling using an organic cell sensing and stimulating transistor (O-CST). We demonstrate that astroglial cells can adhere and proliferate on these devices giving us the possibility to stimulate bioelectrical activity in this type of cells. By the use of a microfluorimetric calcium imaging approach we show that our device is able to evoke an increase in intracellular calcium levels. This research opens a new path in the study of glial cells and their bioelectrical activity.

An organic transistor architecture for stimulation of calcium signalling in primary rat cortical astrocytes

BORRACHERO CONEJO, ANA ISABEL;KARGES, SASKIA KATHARINA;Quiroga, Santiago D.;Caprini, Marco;
2015

Abstract

In this work we report the stimulation of astrocytic calcium signalling using an organic cell sensing and stimulating transistor (O-CST). We demonstrate that astroglial cells can adhere and proliferate on these devices giving us the possibility to stimulate bioelectrical activity in this type of cells. By the use of a microfluorimetric calcium imaging approach we show that our device is able to evoke an increase in intracellular calcium levels. This research opens a new path in the study of glial cells and their bioelectrical activity.
2015
IEEE-NANO 2015 - 15th International Conference on Nanotechnology (CONFERENCE PAPER)
1532
1534
Ana Isabel Borrachero, Conejo; Bonetti, Simone; Karges, Saskia; Pistone, Assunta; Quiroga, Santiago D.; Natali, Marco; Muccini, Michele; Toffanin, Stefano; Grishin, Ilja; Pecqueur, Sebastien; Generali, Gianluca; Caprini, Marco; Benfenati, Valentina
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/574466
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