In this article, we present a mathematical framework based on redundant (non-power) representations of integer numbers as a paradigm for the interpretation of genomic information. The core of the approach relies onmodelling the degeneracy of the genetic code. The model allows one to explain many features and symmetries of the genetic code and to uncover hidden symmetries. Also, it provides us with new tools for the analysis of genomic sequences. We review briefly three main areas: (i) the Euplotid nuclear code, (ii) the vertebrate mitochondrial code, and (iii) the main coding/decoding strategies used in the three domains of life. In every case, we show how the non-power model is a natural unified framework for describing degeneracy and deriving sound biological hypotheses on protein coding. The approach is rooted on number theory and group theory; nevertheless, we have kept the technical level to a minimum by focusing on key concepts and on the biological implications.

The non-power model of the genetic code: A paradigm for interpreting genomic information / Gonzalez, DIEGO LUIS; Giannerini, Simone; Rosa, Rodolfo. - In: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A: MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES. - ISSN 1364-503X. - STAMPA. - 374:2063(2016), pp. 0062.1-0062.16. [10.1098/rsta.2015.0062]

The non-power model of the genetic code: A paradigm for interpreting genomic information

GONZALEZ, DIEGO LUIS;GIANNERINI, SIMONE;ROSA, RODOLFO
2016

Abstract

In this article, we present a mathematical framework based on redundant (non-power) representations of integer numbers as a paradigm for the interpretation of genomic information. The core of the approach relies onmodelling the degeneracy of the genetic code. The model allows one to explain many features and symmetries of the genetic code and to uncover hidden symmetries. Also, it provides us with new tools for the analysis of genomic sequences. We review briefly three main areas: (i) the Euplotid nuclear code, (ii) the vertebrate mitochondrial code, and (iii) the main coding/decoding strategies used in the three domains of life. In every case, we show how the non-power model is a natural unified framework for describing degeneracy and deriving sound biological hypotheses on protein coding. The approach is rooted on number theory and group theory; nevertheless, we have kept the technical level to a minimum by focusing on key concepts and on the biological implications.
2016
The non-power model of the genetic code: A paradigm for interpreting genomic information / Gonzalez, DIEGO LUIS; Giannerini, Simone; Rosa, Rodolfo. - In: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A: MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES. - ISSN 1364-503X. - STAMPA. - 374:2063(2016), pp. 0062.1-0062.16. [10.1098/rsta.2015.0062]
Gonzalez, DIEGO LUIS; Giannerini, Simone; Rosa, Rodolfo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/570928
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