Herein, we describe the first enantioselective cyclopropanation of enals using benzyl chlorides as bifunctional (nucleophilic and electrophilic) reagents. The reaction is simply catalyzed by chiral secondary amines to afford the formyl cyclopropane derivatives in good yields with moderate to excellent stereoselectivities.
Enantioselective Organocatalytic Cyclopropanation of Enals Using Benzyl Chlorides / Meazza, Marta; Ashe, Maria; Shin, Hun Yi; Yang, Hye Sung; Mazzanti, Andrea; Yang, Jung Woon; Rios, Ramon. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - STAMPA. - 81:9(2016), pp. 3488-3500. [10.1021/acs.joc.5b02801]
Enantioselective Organocatalytic Cyclopropanation of Enals Using Benzyl Chlorides
MAZZANTI, ANDREA;
2016
Abstract
Herein, we describe the first enantioselective cyclopropanation of enals using benzyl chlorides as bifunctional (nucleophilic and electrophilic) reagents. The reaction is simply catalyzed by chiral secondary amines to afford the formyl cyclopropane derivatives in good yields with moderate to excellent stereoselectivities.File in questo prodotto:
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