Currently, little is known about differences in miRNA expression between KIT/PDGFRA mutant and KIT/PDGFRA wild-type (WT)-SDH deficient gastrointestinal stromal tumors (GIST). This prompted us to perform an integrated multiple expression profile of miRNA and mRNA, constructing an original miRNA-mRNA regulatory network in KIT/PDGFRA WT-SDH deficient GIST patients.
Integrating miRNA and gene expression profiling analysis revealed regulatory networks in gastrointestinal stromal tumors
PANTALEO, MARIA ABBONDANZA;RAVEGNINI, GLORIA;ASTOLFI, ANNALISA;NANNINI, MARGHERITA;SAPONARA, MARISTELLA;URBINI, MILENA;GATTO, LIDIA;INDIO, VALENTINA;SAMMARINI, GIULIA;SANTINI, DONATELLA;FERRACIN, MANUELA;HRELIA, PATRIZIA;BIASCO, GUIDO;ANGELINI, SABRINA
2016
Abstract
Currently, little is known about differences in miRNA expression between KIT/PDGFRA mutant and KIT/PDGFRA wild-type (WT)-SDH deficient gastrointestinal stromal tumors (GIST). This prompted us to perform an integrated multiple expression profile of miRNA and mRNA, constructing an original miRNA-mRNA regulatory network in KIT/PDGFRA WT-SDH deficient GIST patients.File in questo prodotto:
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