This article reviews medications commonly used for the treatment of patients with functional gastrointestinal disorders. Specifically, we review the animal models that have been validated for the study of drug effects on sensation and motility; the preclinical pharmacology, pharmacokinetics, and toxicology usually required for introduction of new drugs; the biomarkers that are validated for studies of sensation and motility end points with experimental medications in humans; the pharmacogenomics applied to these medications and their relevance to the FGIDs; and the pharmacology of agents that are applied or have potential for the treatment of FGIDs, including psychopharmacologic drugs.

Pharmacologic, pharmacokinetic, and pharmacogenomic aspects of functional gastrointestinal disorders / Camilleri, Michael; Buéno, Lionel; Andresen, Viola; DE PONTI, Fabrizio; Choi, Myung Gyu; Lembo, Anthony. - In: GASTROENTEROLOGY. - ISSN 0016-5085. - STAMPA. - 150:6(2016), pp. 1319-1331e20. [10.1053/j.gastro.2016.02.029]

Pharmacologic, pharmacokinetic, and pharmacogenomic aspects of functional gastrointestinal disorders

DE PONTI, FABRIZIO;
2016

Abstract

This article reviews medications commonly used for the treatment of patients with functional gastrointestinal disorders. Specifically, we review the animal models that have been validated for the study of drug effects on sensation and motility; the preclinical pharmacology, pharmacokinetics, and toxicology usually required for introduction of new drugs; the biomarkers that are validated for studies of sensation and motility end points with experimental medications in humans; the pharmacogenomics applied to these medications and their relevance to the FGIDs; and the pharmacology of agents that are applied or have potential for the treatment of FGIDs, including psychopharmacologic drugs.
2016
Pharmacologic, pharmacokinetic, and pharmacogenomic aspects of functional gastrointestinal disorders / Camilleri, Michael; Buéno, Lionel; Andresen, Viola; DE PONTI, Fabrizio; Choi, Myung Gyu; Lembo, Anthony. - In: GASTROENTEROLOGY. - ISSN 0016-5085. - STAMPA. - 150:6(2016), pp. 1319-1331e20. [10.1053/j.gastro.2016.02.029]
Camilleri, Michael; Buéno, Lionel; Andresen, Viola; DE PONTI, Fabrizio; Choi, Myung Gyu; Lembo, Anthony
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/560860
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