Voriconazole treatment in invasive candidiasis

Although echinocandins are often the preferred front line regimen for uncomplicated Candida bloodstream infections, their penetration into several deep tissue sites, notably the eye and brain, is limited. In these situations, voriconazole can be a useful first line therapy in the treatment of deep-tissue candidiasis involving the eye and CNS, or as a step-down regimen for other complicated infections involving the gastrointestinal tract, heart, lung, and bone.