Chapter 5. Mitochondrial Supercomplexes and ROS Regulation: Implications for Ageing

CONTENTS 5.1 Introduction 5.2 Respiratory Supercomplexes: Structure and Function 5.2.1 Molecular Composition 5.2.2 Dynamic Nature and Kinetic Advantage of Supercomplexes 5.3 ROS Generation by Mitochondria 5.3.1 Respiratory Chain as a Source of ROS 5.3.1.1 Complex I 5.3.1.2 Complex III 5.3.1.3 Other Respiratory Enzymes 5.4 Mitochondrial ROS as Signals: Targets and Mechanisms 5.5 Regulation of Mitochondrial ROS Generation 5.5.1 Role of Mitochondrial Membrane Potential 5.5.2 Role of Post-Translational Modifications 5.5.3 Hypoxia and ROS Production 5.5.4 Role of Supercomplexes 5.6 ROS and Mitochondrial Quality Control 5.7 Implications for Ageing 5.7.1 Unifying Hypothesis Involving Supercomplex Destabilization in Ageing