Hepatitis E is an acute human disease caused by the hepatitis E virus (HEV). In addition to humans, HEV has been detected in several animal species and is recognized as a zoonotic pathogen. Pigs, wild boar and deer can be reservoir. In this study, we evaluated HEV prevalence in a free-living red deer (Cervus elaphus) population in central Italy by detecting virus-specific antibodies and RNA in sera. A total of 35 of 251 red deer sera were positive for anti-HEV IgG. HEV RNA was detected in 10 of 91 sera examined. Two genomic fragments targeted by diagnostic PCRs in the capsid region were sequenced, both matching with genotype 3 HEV. Overall results confirmed the occurrence of HEV infection in deer also in Italy.
Presence of Hepatitis E Virus in a RED Deer (Cervus elaphus) Population in Central Italy / Di Bartolo, I.; Ponterio, E.; Angeloni, G.; Morandi, F.; Ostanello, F.; Nicoloso, S.; Ruggeri, F. M.. - In: TRANSBOUNDARY AND EMERGING DISEASES. - ISSN 1865-1674. - STAMPA. - 64:1(2017), pp. 137-143. [10.1111/tbed.12353]
Presence of Hepatitis E Virus in a RED Deer (Cervus elaphus) Population in Central Italy
OSTANELLO, FABIO;
2017
Abstract
Hepatitis E is an acute human disease caused by the hepatitis E virus (HEV). In addition to humans, HEV has been detected in several animal species and is recognized as a zoonotic pathogen. Pigs, wild boar and deer can be reservoir. In this study, we evaluated HEV prevalence in a free-living red deer (Cervus elaphus) population in central Italy by detecting virus-specific antibodies and RNA in sera. A total of 35 of 251 red deer sera were positive for anti-HEV IgG. HEV RNA was detected in 10 of 91 sera examined. Two genomic fragments targeted by diagnostic PCRs in the capsid region were sequenced, both matching with genotype 3 HEV. Overall results confirmed the occurrence of HEV infection in deer also in Italy.| File | Dimensione | Formato | |
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