Although the limited replicative capacity of human fibroblasts in culture is frequently used as a model for aging, a question of major interest is whether the relationship between in vitro fibroblast proliferative capacity and species longevity is primary or secondary to a relationship with species body size. In this report we establish that body mass is the primary correlative of proliferative potential rather than species life-span.
Cellular replicative capacity correlates primarily with species body mass not longevity / Lorenzini A.; Tresini M.; Austad S.N.; Cristofalo V.J.. - In: MECHANISMS OF AGEING AND DEVELOPMENT. - ISSN 0047-6374. - STAMPA. - 126:(2005), pp. 1130-1133.
Cellular replicative capacity correlates primarily with species body mass not longevity.
LORENZINI, ANTONELLO;
2005
Abstract
Although the limited replicative capacity of human fibroblasts in culture is frequently used as a model for aging, a question of major interest is whether the relationship between in vitro fibroblast proliferative capacity and species longevity is primary or secondary to a relationship with species body size. In this report we establish that body mass is the primary correlative of proliferative potential rather than species life-span.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
