CRIS Current Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishContext: There is a need for the discovery of novel natural remedies to prevent and treat metabolic disorders such as hyperglycemia, type II non-insulin-dependent diabetes mellitus and obesity. Several Achillea species have been utilized for centuries all around the world and are generally considered effective as hypoglycemic. Objective: Considering the ethnobotanical uses of Achillea genus, we evaluated the in vitro inhibitory activity of Achillea tenorii Grande (Asteraceae) extract on α-glcucosidase, which is a valuable target to prevent and treat metabolic disorders. We also tested its antioxidant activity. Moreover, the phytochemical profile was discussed from a chemotaxonomic point of view. Material and methods: In vitro α-glucosidase inhibition of crude ethanolic extract obtained from the aerial parts was assayed as well as the in vitro antioxidant activity (ABTS, DPPH, and FRAP-FZ tests). The extract was characterized by a phytochemical point of view by means of spectroscopic analysis. Results: The extract results endowed with α-glucosidase inhibitory activity (IC50 32 µg/mL) with a particular mechanism of action definable as un-competitive, which differed from the mechanism observed for the best-known α-glucosidase inhibitor (acarbose and miglitol). In addition, a considerable antioxidant potential has been found for A. tenorii extract, which resulted mainly constituted by phenolic compounds as caffeoylquinic acids, and flavonoids. Discussion and conclusions: These results suggest the potential of A. tenorii as a possible natural remedy to prevent and treat metabolic disorders of carbohydrates
| Titolo: | Antioxidant and alfa-glucosidase inhibitory activity of Achillea tenorii | |
| Autore/i: | Alessandro Venditti; Filippo Maggi; Sauro Vittori; Fabrizio Papa; Anna Maria Serrilli; Mirella Di Cecco; Gianpiero Ciaschetti; MANDRONE, MANUELA; POLI, FERRUCCIO; Armandodoriano Bianco | |
| Autore/i Unibo: | ||
| Anno: | 2015 | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.3109/13880209.2014.991833 | |
| Abstract: | Context: There is a need for the discovery of novel natural remedies to prevent and treat metabolic disorders such as hyperglycemia, type II non-insulin-dependent diabetes mellitus and obesity. Several Achillea species have been utilized for centuries all around the world and are generally considered effective as hypoglycemic. Objective: Considering the ethnobotanical uses of Achillea genus, we evaluated the in vitro inhibitory activity of Achillea tenorii Grande (Asteraceae) extract on α-glcucosidase, which is a valuable target to prevent and treat metabolic disorders. We also tested its antioxidant activity. Moreover, the phytochemical profile was discussed from a chemotaxonomic point of view. Material and methods: In vitro α-glucosidase inhibition of crude ethanolic extract obtained from the aerial parts was assayed as well as the in vitro antioxidant activity (ABTS, DPPH, and FRAP-FZ tests). The extract was characterized by a phytochemical point of view by means of spectroscopic analysis. Results: The extract results endowed with α-glucosidase inhibitory activity (IC50 32 µg/mL) with a particular mechanism of action definable as un-competitive, which differed from the mechanism observed for the best-known α-glucosidase inhibitor (acarbose and miglitol). In addition, a considerable antioxidant potential has been found for A. tenorii extract, which resulted mainly constituted by phenolic compounds as caffeoylquinic acids, and flavonoids. Discussion and conclusions: These results suggest the potential of A. tenorii as a possible natural remedy to prevent and treat metabolic disorders of carbohydrates | |
| Data stato definitivo: | 2015-11-18T11:26:40Z | |
| Appare nelle tipologie: |
File in questo prodotto:
Copyright © 2022