Purpose The pseudoexfoliation glaucoma (PEXG) is characterized by the accumulation of abnormal fibrillar materials and pigmented cells in trabecular meshwork. We evaluated if SLT is an effective method to decrease the intraocular pressure (IOP) in patient with PEXG and if it can change the MMP-3/TIMP-1 ratio. Methods We enrolled 20 patients with PEXG, for a total of 40 eyes. The patients had a bad intraocular tensional compensation under maximal medical therapy. The eyes with worst visual field were treated with trabeculectomy while the other eyes with SLT. The aqueous humor was aspirated during surgery and the concentration of MMP-3 and its inhibitor TIMP-1 was assessed. SLT was performed using 50 spots with a size of 400 µm, pulse duration of 3 ns with mean power of 0.572±0.115 mJ. One month after SLT, because the reduction of IOP wasn’t low enough (at least 20% lower than the starting IOP) the patients were treated with trabeculectomy and the MMP-3/TIMP-1 ratio was evaluated. Results At the baseline and after 15 days from SLT, the IOP resulted to be 25,8 ± 1,9 vs. 23,0 ± 1,9 mmHg (p<0,001) but 30 days after the treatment, the IOP rose to 25,4 ± 1,6 mmHg. (p<0.591). The MMP-3 rate in the eyes treated with SLT was 1.817±0.135 ng/mL while the rate quoted in the other control eyes was 1.909±0.205 ng/mL (p<0.177). The TIMP-1 rate was 962.3±33.971 ng/mL and 972.3±24.662 ng/mL (p<0.264) respectively. Before and after SLT treatment MMP3/TIMP-1 ratio resulted to be 0.19. Conclusions Our findings show that the MMP-3/TIMP-1 ratio is not modified by SLT and for this reason the SLT is not effective to treat pseudoexfoliation glaucoma. Nevertheless our results need to be verified in a greatest number of PEXG patients.
Selective laser trabeculoplasty in pseudoexfoliation secondary glaucoma / CELLINI M.; LEONETTI P.; ZAMPARINI E.; CAMPOS E.C.. - In: ACTA OPHTHALMOLOGICA SCANDINAVICA. - ISSN 1395-3907. - STAMPA. - 84 suppl 239:(2006), pp. 55-55. (Intervento presentato al convegno EVER 2006 tenutosi a Vilamoura (Portugal) nel 4 - 7 Ottobre 2006).
Selective laser trabeculoplasty in pseudoexfoliation secondary glaucoma.
CELLINI, MAURO;LEONETTI, PIETRO;CAMPOS, EMILIO
2006
Abstract
Purpose The pseudoexfoliation glaucoma (PEXG) is characterized by the accumulation of abnormal fibrillar materials and pigmented cells in trabecular meshwork. We evaluated if SLT is an effective method to decrease the intraocular pressure (IOP) in patient with PEXG and if it can change the MMP-3/TIMP-1 ratio. Methods We enrolled 20 patients with PEXG, for a total of 40 eyes. The patients had a bad intraocular tensional compensation under maximal medical therapy. The eyes with worst visual field were treated with trabeculectomy while the other eyes with SLT. The aqueous humor was aspirated during surgery and the concentration of MMP-3 and its inhibitor TIMP-1 was assessed. SLT was performed using 50 spots with a size of 400 µm, pulse duration of 3 ns with mean power of 0.572±0.115 mJ. One month after SLT, because the reduction of IOP wasn’t low enough (at least 20% lower than the starting IOP) the patients were treated with trabeculectomy and the MMP-3/TIMP-1 ratio was evaluated. Results At the baseline and after 15 days from SLT, the IOP resulted to be 25,8 ± 1,9 vs. 23,0 ± 1,9 mmHg (p<0,001) but 30 days after the treatment, the IOP rose to 25,4 ± 1,6 mmHg. (p<0.591). The MMP-3 rate in the eyes treated with SLT was 1.817±0.135 ng/mL while the rate quoted in the other control eyes was 1.909±0.205 ng/mL (p<0.177). The TIMP-1 rate was 962.3±33.971 ng/mL and 972.3±24.662 ng/mL (p<0.264) respectively. Before and after SLT treatment MMP3/TIMP-1 ratio resulted to be 0.19. Conclusions Our findings show that the MMP-3/TIMP-1 ratio is not modified by SLT and for this reason the SLT is not effective to treat pseudoexfoliation glaucoma. Nevertheless our results need to be verified in a greatest number of PEXG patients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
