Our findings support a model in which the GSK3 pathway can exerts a negative control on p75NTR transcription in high risk neuroblastoma and highlight the possibility to use GSK3 inhibitors as potential therapeutic drugs to treat neuroblastoma with low p75NTR.
A genome-scale shRNA screen identifies GSK3 as a critical regulator of p75NTR transcription in high risk neuroblastoma
PERINI, GIOVANNI;VALLI, EMANUELE;GHERARDI, SAMUELE;DI GIACOMO, SIMONE;MILAZZO, GIORGIO;
2012
Abstract
Our findings support a model in which the GSK3 pathway can exerts a negative control on p75NTR transcription in high risk neuroblastoma and highlight the possibility to use GSK3 inhibitors as potential therapeutic drugs to treat neuroblastoma with low p75NTR.File in questo prodotto:
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