Chlorotoxin-targeted polymeric nanoparticles containing entrapped gold nanorods as potential therapeutic agent for glioblastoma multiforme have been developed and evaluated. In first proof of concept experiments, in vitro specific uptake in cancer cells and selective laser-induced cell death have been shown. In vivo studies with optical imaging showed increased retention of targeted NPs in the tumor.
Targeted polymeric nanoparticles containing gold nanorods: a therapeutic approach against glioblastoma / Erica Locatelli;Wolfgang Bost;Marc Fournelle;Jordi Llop;Larraitz Gil;Francesca Arena;Vito Lorusso;Mauro Comes Franchini. - In: JOURNAL OF NANOPARTICLE RESEARCH. - ISSN 1388-0764. - STAMPA. - 16:(2014), pp. 2304-2312. [10.1007/s11051-014-2304-7]
Targeted polymeric nanoparticles containing gold nanorods: a therapeutic approach against glioblastoma
LOCATELLI, ERICA;COMES FRANCHINI, MAURO
2014
Abstract
Chlorotoxin-targeted polymeric nanoparticles containing entrapped gold nanorods as potential therapeutic agent for glioblastoma multiforme have been developed and evaluated. In first proof of concept experiments, in vitro specific uptake in cancer cells and selective laser-induced cell death have been shown. In vivo studies with optical imaging showed increased retention of targeted NPs in the tumor.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
