With the aim of designing a new calcium receptor, the synthesis and the conformational analysis of a small library of dipeptides having general formula Ac-Oxx-L-Xaa-OBn [Oxx = L-Oxd, (4S,5R)-4-methyl-5-carboxyoxazolidin-2-one; D-Oxd, (4R,5S)-4-methyl-5-carboxyoxazolidin-2-one; or D-Oxac (4R)-(2-oxo-1,3-oxazolidin-4-yl)-acetic acid] is reported. Ac-L-Oxd-L-Ala-OBn was identified as the most promising compound by MS-ESI analysis and this outcome was confirmed by photoluminescence spectroscopy.
Development of New Calcium Receptors Based on Oxazolidin-2-ones Containing Pseudopeptides / G. Luppi; A. Garelli; L. Prodi; Q. B. Broxterman; B. Kaptein; C. Tomasini. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - STAMPA. - 3:(2005), pp. 1520-1524. [10.1039/b501017a]
Development of New Calcium Receptors Based on Oxazolidin-2-ones Containing Pseudopeptides
LUPPI, GIANLUIGI;GARELLI, ANDREA;PRODI, LUCA;TOMASINI, CLAUDIA
2005
Abstract
With the aim of designing a new calcium receptor, the synthesis and the conformational analysis of a small library of dipeptides having general formula Ac-Oxx-L-Xaa-OBn [Oxx = L-Oxd, (4S,5R)-4-methyl-5-carboxyoxazolidin-2-one; D-Oxd, (4R,5S)-4-methyl-5-carboxyoxazolidin-2-one; or D-Oxac (4R)-(2-oxo-1,3-oxazolidin-4-yl)-acetic acid] is reported. Ac-L-Oxd-L-Ala-OBn was identified as the most promising compound by MS-ESI analysis and this outcome was confirmed by photoluminescence spectroscopy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
