The paper describes the design of a smart sensor for label-free detection of DNA hybridization. The sensor is based on a direct electrical transduction principle: it measures impedance variation at the interface between a bio-functionalized electrode and a solution containing the analyte. The smart sensor includes a complete signal conditioning and processing subsystem based on an embedded μ-controller. We outline the sensor architecture, and we describe in detail board-level integration as well as hardware and software implementation and design choices. The accuracy of our embedded solution has been evaluated by comparing it with a high-cost laboratory setup. Moreover, we provide measurements of real sensing structures which demonstrate the functionality of our system in the field
Hardware-Software Design of a Smart Sensor for Fully-Electronic DNA Hybridization Detection
STAGNI DEGLI ESPOSTI, CLAUDIO;GUIDUCCI, CARLOTTA;LANZONI, MASSIMO;BENINI, LUCA;RICCO', BRUNO
2005
Abstract
The paper describes the design of a smart sensor for label-free detection of DNA hybridization. The sensor is based on a direct electrical transduction principle: it measures impedance variation at the interface between a bio-functionalized electrode and a solution containing the analyte. The smart sensor includes a complete signal conditioning and processing subsystem based on an embedded μ-controller. We outline the sensor architecture, and we describe in detail board-level integration as well as hardware and software implementation and design choices. The accuracy of our embedded solution has been evaluated by comparing it with a high-cost laboratory setup. Moreover, we provide measurements of real sensing structures which demonstrate the functionality of our system in the fieldI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.