Aim: reactive oxigen species (ROS) have a well-estabilished role in the athogenesis of many forms of malignancy and superoxide dismutase(SODs) are the only enzymes dismuting one of the main radicals: the superoxide anion. Since many human tumors have shown significant changes in the activity and expression of SODs, this enzyme might be correlated with survival and clinical-pathological parameters for the prognosis of human carcinoma. This preliminary study were performed to assess the SODs(CuZnSOD and MnSOD) activity and expression in gastric adenocarcinoma with respect to healthy tissue using western blotting (W-B) technique as a specific and sensible clinical test.
Superoxide dismutase expression in gastric adenocarcinoma: a clinical biomarker in the development of cancer.
MONARI, MARTA;CATTANI, OTELLO;TUGNOLI, VITALIANO;DI FEBO, GIULIO;TRINCHERO, ANDREA
2005
Abstract
Aim: reactive oxigen species (ROS) have a well-estabilished role in the athogenesis of many forms of malignancy and superoxide dismutase(SODs) are the only enzymes dismuting one of the main radicals: the superoxide anion. Since many human tumors have shown significant changes in the activity and expression of SODs, this enzyme might be correlated with survival and clinical-pathological parameters for the prognosis of human carcinoma. This preliminary study were performed to assess the SODs(CuZnSOD and MnSOD) activity and expression in gastric adenocarcinoma with respect to healthy tissue using western blotting (W-B) technique as a specific and sensible clinical test.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
