Benzo[a]pyrene among PAHs is the most pollutant investigated for its toxicity and carcinogenicity. In vertebrates, the CYP1A subfamily members represent the main forms of P450 associated with exposures to PAHs and the P450 dependent oxidative metabolism of B[a]P leads to the production of ROS (mostly O2-•). About this, SOD represents an appropriate response to oxidative injury as a mechanism of protection against increasing ROS levels. This research was focused on the study of the induction of CYP 1A and Mn-SOD, involved in detoxification processes, in hepatopancreas of Scapharca inaequivalvis (Adriatic bivalve) exposed to B[a]P. Scapharca specimens were exposed to 0.44 mg B[a]P.
IMMUNOCHEMICAL INVESTIGATION OF CYP 1A AND Mn-SOD IN SCAPHARCA INAEQUIVALVIS EXPOSED TO BENZO[a]PYRENE
MONARI, MARTA;SERRAZANETTI, GIAN PAOLO;FOSCHI, JURGEN;CATTANI, OTELLO
2005
Abstract
Benzo[a]pyrene among PAHs is the most pollutant investigated for its toxicity and carcinogenicity. In vertebrates, the CYP1A subfamily members represent the main forms of P450 associated with exposures to PAHs and the P450 dependent oxidative metabolism of B[a]P leads to the production of ROS (mostly O2-•). About this, SOD represents an appropriate response to oxidative injury as a mechanism of protection against increasing ROS levels. This research was focused on the study of the induction of CYP 1A and Mn-SOD, involved in detoxification processes, in hepatopancreas of Scapharca inaequivalvis (Adriatic bivalve) exposed to B[a]P. Scapharca specimens were exposed to 0.44 mg B[a]P.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
