Most of the enzymes involved in such biotransformation, including cytochrome P450 monooxygenase or mixed function oxygenase (MFO) systems have been identified in marine vertebrates and invertebrates. Several studies suggest that during phase I reactions cytochrome P450 and the flavoprotein reductase components of the MFO system are involved in the formation of oxygen free radicals or metabolite radicals. Since the oxyradical generation causes biological damage, the integrity of the cell is protected by antioxidant defences. Antioxidant enzymes as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), play a crucial role in maintaining cell homeostasis. The aim of this work is to study the induction of cytochrome P450 after B[a]P exposure in Scapharca inaequivalvis and the relationship between the level of the antioxidant defences and P450 content
RESPONSE OF THE BLOOD CLAM SCAPHARCA INAEQUIVALVIS (MOLLUSCA, BIVALVIA) TO BENZO[a]PYRENE EXPOSURE / M. Monari; G.P. Serrazanetti; J. Foschi; G. Isani ; E. Zironi; O.Cattani. - In: ITALIAN JOURNAL OF BIOCHEMISTRY. - ISSN 0021-2938. - STAMPA. - 53(3):(2004), pp. 134-134. (Intervento presentato al convegno 49°Congresso SIB tenutosi a Riccione (RN) nel 28 settebre-1 ottobre 2004).
RESPONSE OF THE BLOOD CLAM SCAPHARCA INAEQUIVALVIS (MOLLUSCA, BIVALVIA) TO BENZO[a]PYRENE EXPOSURE
MONARI, MARTA;SERRAZANETTI, GIAN PAOLO;FOSCHI, JURGEN;ISANI, GLORIA;ZIRONI, ELISA;CATTANI, OTELLO
2004
Abstract
Most of the enzymes involved in such biotransformation, including cytochrome P450 monooxygenase or mixed function oxygenase (MFO) systems have been identified in marine vertebrates and invertebrates. Several studies suggest that during phase I reactions cytochrome P450 and the flavoprotein reductase components of the MFO system are involved in the formation of oxygen free radicals or metabolite radicals. Since the oxyradical generation causes biological damage, the integrity of the cell is protected by antioxidant defences. Antioxidant enzymes as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), play a crucial role in maintaining cell homeostasis. The aim of this work is to study the induction of cytochrome P450 after B[a]P exposure in Scapharca inaequivalvis and the relationship between the level of the antioxidant defences and P450 contentI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
