We present a case of inflammatory myofibroblastic tumour (IMT) of the trachea arising in a young woman. The patient presented with acute upper airway obstruction, dyspnoea and cough. At videobronchoscopy, the lesion appeared as a smooth, pink, polipoid mass of 1,5 cm obstructing the 70% of the tracheal lumen. The mass was endoscopically removed. Histopathologic examination revealed a lesion composed of spindle shaped cells admixed with a prominent inflammatory infiltrate, which included hystiocytes, plasma cells and lymphocytes. Immunohistochemical studies revealed that the spindle cells were reactive with anti-vimentin, while cytokeratin, S-100, smooth muscle actin, CD21, CD23, CD34 and CD31 were all consistently negative. The proliferative index, shown by Ki67 antibody, was about 7% . Two years after diagnosis , the patient is well without evidence of disease. IMT of the respiratory tract occurs more frequently in the lung. To the best of our knowledge there are only 2 previously reported cases of tracheal IMT. This type of lesion, has to be differentiated from malignant neoplasms such as spindle cell carcinoma and fibrosarcoma
Inflammatory Myofibroblastic Tumour Of The Trachea
CAPRARA, GIACOMO;ASIOLI, SOFIA;DAMIANI, STEFANIA
2005
Abstract
We present a case of inflammatory myofibroblastic tumour (IMT) of the trachea arising in a young woman. The patient presented with acute upper airway obstruction, dyspnoea and cough. At videobronchoscopy, the lesion appeared as a smooth, pink, polipoid mass of 1,5 cm obstructing the 70% of the tracheal lumen. The mass was endoscopically removed. Histopathologic examination revealed a lesion composed of spindle shaped cells admixed with a prominent inflammatory infiltrate, which included hystiocytes, plasma cells and lymphocytes. Immunohistochemical studies revealed that the spindle cells were reactive with anti-vimentin, while cytokeratin, S-100, smooth muscle actin, CD21, CD23, CD34 and CD31 were all consistently negative. The proliferative index, shown by Ki67 antibody, was about 7% . Two years after diagnosis , the patient is well without evidence of disease. IMT of the respiratory tract occurs more frequently in the lung. To the best of our knowledge there are only 2 previously reported cases of tracheal IMT. This type of lesion, has to be differentiated from malignant neoplasms such as spindle cell carcinoma and fibrosarcomaI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
