Abstract PURPOSE: Crotamiton is a topical drug used in the treatment of scabies and pruritus. We determined its percutaneous absorption following single and multiple dosing in normal skin. METHODS: We used in vivo measurement of percutaneous absorption of [14C] crotamiton in a multidose regimen by measuring urinary excretion and liquid scintillation counting in three groups of four healthy volunteers. The Feldmann urinary excretion method was utilized to ascertain percutaneous absorption. Our results showed that tape stripping does not increase percutaneous absorption of crotamiton; upon repeated application.
Percutaneous absorption of crotamiton in man following single and multiple dosing Cutan Ocul Toxicol / Dika E; Varotti C; Bardazzi F; Maibach HI.. - In: CUTANEOUS AND OCULAR TOXICOLOGY. - ISSN 1556-9527. - ELETTRONICO. - 25 (3):(2006), pp. 211-216.
Percutaneous absorption of crotamiton in man following single and multiple dosing Cutan Ocul Toxicol
DIKA, EMI;
2006
Abstract
Abstract PURPOSE: Crotamiton is a topical drug used in the treatment of scabies and pruritus. We determined its percutaneous absorption following single and multiple dosing in normal skin. METHODS: We used in vivo measurement of percutaneous absorption of [14C] crotamiton in a multidose regimen by measuring urinary excretion and liquid scintillation counting in three groups of four healthy volunteers. The Feldmann urinary excretion method was utilized to ascertain percutaneous absorption. Our results showed that tape stripping does not increase percutaneous absorption of crotamiton; upon repeated application.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
