The polymorphism of racemic imidazol-1ylsuccinic acid derivatives, a series of compounds previously used as extracellular pH probes for NMR spectroscopy, is investigated by crystallization in different solvents. The mono-ester, (±)-3-(ethoxycarbonyl)-2-(imidazol-1-yl) propionic acid, shows two different polymorphs when recrystallized in absolute ethanol (Form I) or water (Form II), respectively. These two forms have been characterized by optical microscopy, powder X-ray diffraction analysis, and thermogravimetry. Polymorphs I and II can also be distinguished by solid state CP-MAS 13C NMR spectroscopy.
Polymorphism of racemic imidazol-1-ylsuccinic acid derivatives. Suitable probes for extracellular pH by magnetic resonance spectroscopic imaging
RIGHI, VALERIA;
2011
Abstract
The polymorphism of racemic imidazol-1ylsuccinic acid derivatives, a series of compounds previously used as extracellular pH probes for NMR spectroscopy, is investigated by crystallization in different solvents. The mono-ester, (±)-3-(ethoxycarbonyl)-2-(imidazol-1-yl) propionic acid, shows two different polymorphs when recrystallized in absolute ethanol (Form I) or water (Form II), respectively. These two forms have been characterized by optical microscopy, powder X-ray diffraction analysis, and thermogravimetry. Polymorphs I and II can also be distinguished by solid state CP-MAS 13C NMR spectroscopy.File in questo prodotto:
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