We have described the first organocatalytic stereoselective formylation of ketones accomplished by the use of N-methybenzothiazolylium iodide. The benzothiazolium salt, generally used as a masked formyl group or as precursor of carbenes,[31] is quite electrophilic and react with enamines formed in situ. Both moderate yield and high stereoselectivity were obtained with different ketones.
Organocatalytic Stereoselective α-Formylation of Ketones / Capdevila, M G; Emer, E; Gualandi, A; Petruzziello, D; Grilli, S; Cozzi, P G. - In: CHEMCATCHEM. - ISSN 1867-3880. - STAMPA. - 4:7(2012), pp. 968-971. [10.1002/cctc.201200122]
Organocatalytic Stereoselective α-Formylation of Ketones
GUALANDI, ANDREA;GRILLI, STEFANO;COZZI, PIER GIORGIO
2012
Abstract
We have described the first organocatalytic stereoselective formylation of ketones accomplished by the use of N-methybenzothiazolylium iodide. The benzothiazolium salt, generally used as a masked formyl group or as precursor of carbenes,[31] is quite electrophilic and react with enamines formed in situ. Both moderate yield and high stereoselectivity were obtained with different ketones.File in questo prodotto:
Eventuali allegati, non sono esposti
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
