Our study aims at replicating our previous finding of an association between COMT rs4680 G/A polymorphism and early onset major depression (MD). We included 462 MD, 147 bipolar disorders (BD) subjects and 295 healthy controls. We could partially replicate previous findings. In particular, rs4680 GG+AG genotypes were more represented in the subgroup of early onset MD patients (p=0.04). Additionally, we observed an association between rs737865 alleles and early onset MD (p=0.04). Rs4680 genotype was associated with early onset BD as well (p=0.01). In conclusion, we partially replicated our previous findings confirming a possible influence of COMT variants in MD and BD, particularly in early onset subjects, though not with the same risk genotypes.
COMT and age at onset in mood disorders: a replication and extension study / Massat I.; Kocabas N.A.; Crisafulli C.; Chiesa A.; Calati R.; Linotte S.; Kasper S.; Fink M.; Antonijevic I.; Forray C.; Snyder L.; Bollen J.; Zohar J.; De Ronchi D.; Souery D.; Serretti A.; Mendlewicz J.. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - STAMPA. - 498:(2011), pp. 218-221. [10.1016/j.neulet.2011.05.012]
COMT and age at onset in mood disorders: a replication and extension study.
CALATI, RAFFAELLA;DE RONCHI, DIANA;SERRETTI, ALESSANDRO;
2011
Abstract
Our study aims at replicating our previous finding of an association between COMT rs4680 G/A polymorphism and early onset major depression (MD). We included 462 MD, 147 bipolar disorders (BD) subjects and 295 healthy controls. We could partially replicate previous findings. In particular, rs4680 GG+AG genotypes were more represented in the subgroup of early onset MD patients (p=0.04). Additionally, we observed an association between rs737865 alleles and early onset MD (p=0.04). Rs4680 genotype was associated with early onset BD as well (p=0.01). In conclusion, we partially replicated our previous findings confirming a possible influence of COMT variants in MD and BD, particularly in early onset subjects, though not with the same risk genotypes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
