During the last decade a tremendous technologic progress based on genome-wide profiling of genetic aberrations, structural DNA alterations, and sequence variations has allowed a better understanding of the molecular basis of pediatric and adult B/T-acute lymphoblastic leukemia (ALL), contributing to a better recognition of the biological heterogeneity of ALL and to a more precise definition of risk factors. Importantly, these advances identified novel potential targets for therapeutic intervention. This review will be focused on the cytogenetic/molecular advances in pediatric and adult ALL based on recently published articles.
Cytogenetic and molecular predictors of outcome in acute lymphocytic leukemia: recent developments / Iacobucci I; Papayannidis C; Lonetti A; Ferrari A; Baccarani M; Martinelli G.. - In: CURRENT HEMATOLOGIC MALIGNANCY REPORTS. - ISSN 1558-8211. - STAMPA. - 7(2):(2012), pp. 133-143. [10.1007/s11899-012-0122-5]
Cytogenetic and molecular predictors of outcome in acute lymphocytic leukemia: recent developments.
IACOBUCCI, ILARIA;PAPAYANNIDIS, CRISTINA;LONETTI, ANNALISA;FERRARI, ANNA;BACCARANI, MICHELE;MARTINELLI, GIOVANNI
2012
Abstract
During the last decade a tremendous technologic progress based on genome-wide profiling of genetic aberrations, structural DNA alterations, and sequence variations has allowed a better understanding of the molecular basis of pediatric and adult B/T-acute lymphoblastic leukemia (ALL), contributing to a better recognition of the biological heterogeneity of ALL and to a more precise definition of risk factors. Importantly, these advances identified novel potential targets for therapeutic intervention. This review will be focused on the cytogenetic/molecular advances in pediatric and adult ALL based on recently published articles.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
