A simple method for the synthesis of lipophilic Ag NPs have been developed. The coated Ag NPs have been entrapped into a FDA-approved and targetable PEG-based polymeric nanoparticles, and this nanocarrier has been conjugated with the peptide chlorotoxin. Uptake experiments have shown a cell-specific recognition of the Ag-1-PNPs-Cltx on U87MG cell lines in comparison to Balb/3T3. The uptake of Ag into the cells was quantified and an interesting cytotoxic effect (IC50= 45 M) has been found on glioblastoma cell lines.
Lipophilic Silver Nanoparticles and Their Polymeric Entrapment into Targeted-PEG-based micelles for the treatment of Glioblastoma / E. Locatelli; F. Broggi; J. Ponti; P. Marmorato; F. Franchini; S. Lena; M. Comes Franchini. - In: ADVANCED HEALTHCARE MATERIALS. - ISSN 2192-2659. - STAMPA. - 1:(2012), pp. 342-347. [10.1002/adhm.201100047]
Lipophilic Silver Nanoparticles and Their Polymeric Entrapment into Targeted-PEG-based micelles for the treatment of Glioblastoma.
LOCATELLI, ERICA;COMES FRANCHINI, MAURO
2012
Abstract
A simple method for the synthesis of lipophilic Ag NPs have been developed. The coated Ag NPs have been entrapped into a FDA-approved and targetable PEG-based polymeric nanoparticles, and this nanocarrier has been conjugated with the peptide chlorotoxin. Uptake experiments have shown a cell-specific recognition of the Ag-1-PNPs-Cltx on U87MG cell lines in comparison to Balb/3T3. The uptake of Ag into the cells was quantified and an interesting cytotoxic effect (IC50= 45 M) has been found on glioblastoma cell lines.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
