Alcohol dehydrogenases are enzymes involved in natural oxidoreductive interconversions between alcohols and aldehydes. In particular Horse Liver Alcohol Dehydrogenase (HLADH) is an interesting enzyme and it has been used in several chemical processes. In a research project on the development of a chemoenzymatic synthesis of Profens we used HLADH for the asymmetric reduction of several racemic 2-arylpropanals to (2S)-arylpropanols. Optimized reaction conditions in a buffer–organic medium, allowed the occurrence of a dynamic kinetic resolution (DKR) process
ALCOHOL DEHYDROGENASES AND BIOACTIVE MOLECULES: AN APPLICATION IN THE SYNTHESIS OF PROFENS / Daria Giacomini; Paola Galletti; Matteo Pori. - STAMPA. - (2011), pp. ...-.... (Intervento presentato al convegno Italian Industrial Biotech 2011 di Milano tenutosi a Milano nel 29 novembre 2011).
ALCOHOL DEHYDROGENASES AND BIOACTIVE MOLECULES: AN APPLICATION IN THE SYNTHESIS OF PROFENS
GIACOMINI, DARIA;GALLETTI, PAOLA;PORI, MATTEO
2011
Abstract
Alcohol dehydrogenases are enzymes involved in natural oxidoreductive interconversions between alcohols and aldehydes. In particular Horse Liver Alcohol Dehydrogenase (HLADH) is an interesting enzyme and it has been used in several chemical processes. In a research project on the development of a chemoenzymatic synthesis of Profens we used HLADH for the asymmetric reduction of several racemic 2-arylpropanals to (2S)-arylpropanols. Optimized reaction conditions in a buffer–organic medium, allowed the occurrence of a dynamic kinetic resolution (DKR) processI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
